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The usual starting dose for adults is 15 mg or 30 mg taken once daily. You and your doctor should consider the risk of fractures. Histological examination reveals signs of cytolytic or mixed hepatitis: hepatocyte necrosis, which predominates in central lobular lobes in combination with periportal inflammatory infiltration and vacuolation of the cytoplasm. Linked to an increased risk of bladder cancer. Clinically, it is manifested by acute renal failure. Remember, the cornerstone of diabetes control is unchanged: it is important to follow a meal plan and to get plenty of physical activity. Tell your doctor if you have any side effect that bothers you or that does not go away.